Biological Residues (Control) Regulations 1985 (S.I. No. 9 of 1985)

STATUTORY INSTRUMENT No. 9 of 1985 REOULArlONS m4tk by tlw Mtn,mr (If Htalth., lobtJflr and S,ottt /It ff:Krrciu vf IM JIOtl'trs c-onf~m1d ~pon l,im by Strtion I I (If tM Food and Dt-UK$ Ordln.onct Chopttt 219 of tllt' Ldws of Btll:11 a.r a,nn,dt!d QM aU o,hr, po"''"' thnnnt<11,/m t1Wbl1ng, (Gatrtml 9th FrbrlUlty, 1985) The8C RCJl,llationa tn1Y l:l(l cited u BtOLOGICAL llESlOUES (CONTilOL) REGULATIONS 198$ 2. In tM!lle R.qul.ttio,u► the foUowlna exprol!'l!dl'n11 ehall have tho mean• inp ~by IIMIIJ\t(I to tht111! "~jve prindple'' mtam any ~ lllQba~ whkh JiYel'I any pttlduct the 'Nltute \.'IC the ~dcldo •~ic to it. "Aci.mal" meui11 the nMi le, fcm.alt or young of any < t the rollowm, 11J)OCJQ'l, cattle, 111\ecp, go1.t, 11wine, bol'fle or poultry (c;hkken, duck, aoo,,c, wrtey. guirk)a[OWl, pl'lea.8UII) "A1.i;h0rized Offiee1 .. mclllflll a Medical Officer of Hm.ftht Vetd'iflU'UIC'I, or any~ authcriffit b,y tlM:I Mlni.11et for U,e pur~ pol!,t o( the:etl ltq\u1fLtklM. "Bioloaical f'tlljduc" meant the raiidue of J.llY IIU~ indudin, mep,001.k; ~uelb; mclaOOli1'ull n:01&11.iuf 1q ilio loi!ltl'.I\IQ.uid orp.1111 of animala af'ttt 1d.aughtei 1111 a l'l!IIUlt or trta\menl or exptaure of the -.nitnall to a J.'ICl'lticidc. t,c:rt,icide. fungicide. otglUlk: ot ~ com.l)OUl"ld; hormone 01 t-ormone-like tubtltance. ,MtOW&h promota, antibiotic, anthdmimi.c. t1anql.li].i!lct or QCllcr therapeutic or pro­ phy1-.-u~ 1 pll\ll, "Lot .. mcat11 & ma\imum or 30 bOVinm or one day'11 throuahput if auch -.nim&II cot'l'IO l'tom the wnc ownor or lfO'll'(f OI • IMP• nnch, farm c>r fatteninl lot. wtuer it eeparato ftom other u nna 800 lhall irlctude the ~ and n . .c trom ~ ~ It U.c nu 'llbl:ic or •u.l.m•la r.rom. ono ao\ll'GIO ill loM Chu 30 &.hco tNt num'(Jc, coni,litute \ho wt sizt. "'Offida1 t..boratory .. mconi ,ny lflbo1at:or, authort. by the Minilte. fC't &hr' putJ'(lllCIII of' ffieM ReauWm .. Paltk:ido" m.na ,ny lllubf,taocc or nmtl.n of•ubllbuxm mod CO 11pri w WJJ'fnrl 11r,y ton» vl ,Nl))OltJ 01' pJilnt lilo ottw, ~ mM and o\hertbaa t,a,;:lelia. virut tnd ottm micro-otpl1llml oa ot bl Uvina nm or other lMna animalL'l that aft'cetl the belletl or the en~ 111d shall incll.MIO ~•. nernat.oc:ldcla, acaric::idel b<ttricldoo, I~ ..... lo, )lonnonol 1114 """""1>o,lko nanca, IIUlpfAlanddca. MU-bhXM aod (;OQ(J~ ftot1 TltJe ......... A11thoriffd ()ffi<ler 10 ta1u11mplrt1 ""Tolerance level" ffl'!&l'l8 that lcwl or biological miidue which dOOII not render the meat. poultry or m¢t\t product una~blo WJ'.,;a.tly oi imlire,...tly (o, hwn,411 ..:um,wupt.ion, "Withdnl,wal ii.me" mean1t the minimum period ortllno necnuuy tar any 11ubtoltancc UdOd in the treatment of an animal. to be climinattd or rodu«d to the tolerance k·:cl, !IO that on the da.y the &r'li.mal ~, l)n':ll'ltnted for elauphtier, in the ani naJ IIO ~t:eJ or e-1.p•.Ma.1 to "ui;h ,iub<,t.i.ri=~, any u,.,,Jduc will w:,t «in\.Ji;t the meat hannful or ~ptablt for tiumari food. 3. Tbe Authorized, Orricc, l!lhall have the authority to take s~ 11a.mrlC!'I a11 he ~eems necc11 .ary for the determination of Diological rc:BldUC8. 4. (a) The Authorized OITicct ahaU conduct a ,egulat 1utvellianco otthc bioJog.ical l'Cftid1,1ct1 in anima111 lcing11laughtercd, (b) I le othall ffl:rtituto o. IIQ.Rlplin. progt\Vl'lffl~ tuing into QOD• 11id1:1"4!0o too a.nt-:mortern arul postmo:ti:;m. 11igru1., ti.le 'ru&toty of the r11.rm and ar.:a (((Im which ttte ani.maJJJ come and tho c:hetnic&l~ and/or dtup used on the farm. (.r) Sueh s:unt1les sh.:1.11 be taken acoordii\i to tho phd:I or the in,, wauca.tton~ which sh.all in t.ie (i.t9t inl!ta.nce be an investiptory phll,,e, follawc-d by t,\C ~nd or routine "urvei(lanco phase, HO'Wc:Vet, in any known or l!IUfllj)CdJd ,dtuation of biological l'elliduc abwlc ot accident mo~ interufr,,e umplin1 may be inlltml~ .,.. d~ n ~"Y hy tht: Millllltm'. (I} In the inve,t:ip.tory pha.,e,. the anutlill.$ of & \ot lhl.\\ be rarndomly sdccted and one aet or samplea •hall be taken r mm the carca.• or mc.t.t or each animal,, miuirnwn ono to ten~ folJOWII : No. ef Animal.r In tht Lot 1 -· $ 6- JO U .-15, 16 - 20 21 - 30 I 2 $ • ' {!f) WIICl't the animals are or unknown or undiAclOIIOd oriaift the ~OJ or .mi:::at or al\ 11~ •nimAl"' ,ba.11 bro Am~ (Ill) AU CIU"Cllllld or meat or auch animalf ahal1 bo M&iDed t,y t, . Aufoori.l.ed omecr pending tho rew.-cipt of tho laboratory rc;ilultl, (Iv) In tile in\lC5tiaatory pha~ tM: rate ot tcltmg s\w\ be OM per lot for Cltlorina.t~d Hydro.:atbo1l8' 01'1&110~ cn,-ironmental contarninl,nt8; antibloticB and ono per w«:k (or hormoncn •nd r-,,, 1- ., l'Nlbl■• (v) In the ruut\11C 11ur,;eilla.ncc phuc llolffl.Plell ah,ll be taken from tandontly 11¢lc.lctcd Q.ml.'lftelll or .meat or atlil'l'lilMI at aOOut half the rr.te of 14llmpling u~ in the in~ry pha.~e. (d) F.ach ti!l!!i,w:: Rhall be Jl&Cked in a 11eparatc pla'ltic bag. r,ozen Kuidlit1ior and forwarded \\<hilllt maint.\in«t in a froien llt~t-e to the of- S..mflltl f1cial laboratory for thr dctcnn.inatlon of biological retidueii. (t') Sample, for hitrtolo~cal eu.mination1 Khall include all ab­ normal tiMucs and the normal i1~ut11. 1,1 hich "h::ill inthi.d~ heart, liver, Kpleen, kidney, bra.in and tnUIICle and th* shall be from 1/4" t.., 1 /2" thick and pre11c:rvcd in 10!{. buffered ror• m.ilin. (/J All llaITlplCH 11ha1\ be accomr,anled by a laboratory ~1.•::in l'iftl form (Al a-. prCMCr;bed ln the Fio-t Schedule, st1ting the Sl.llltlduk anulwiR requO'tcd, 11r,eclc,i of animal, type ofti~ue~ submitted name and add.rco.M of Ellt.Lbfo1hrncnt, name and ad~ of tho own« or t'1e animal and of t'1e fa"m, roe<llot, or ot'1Cf R<h.1m:1 of the anlmat11. --. he type or u~ue antl amouM", 'UI tie Seco:,d 1mbn1tcd ,re specified in the M:COnd ~chedule. !k,..<,1u1c, (g) Sarnrl~ llh.'\11 be taken in du\'llici-te and the duplicate wnpie shall be n.t.1ined by the Authoriud oHicer pending Jle re. ('cPir,t nrtlv! lahnratn")' N'Mnlt-.. th) The methtlJ11 of analyi.iM Mhall be tliO!le Bpecified by the Mini11• ter in tne ReP,ulation11, (i) ihe laboratory rt:11ultJJ shall be reported on the form B u pre,- Fi"t ibwd by the fiM AQh<tdvl.,, S..bedull! 5, The Authorized Officer flh:dl k;e~p a rcc;ord of all 11ample1! flubmittNI ll«Ofd• to tor ana,JyKi!I and the reco1d 11t,all 11h0\\< the 11:,eci;s or animali1, origin of the be tepc animal {f1'1'm and Ownc1) and the lal:Klr,tory findinp. The Authorized O!Tk;>;a 11111111 o,ubmit • monthly n:port of ti- to th,; Mini"1il;r. 6. Tolerance levelll for biologi::d N'!iduc,i 11hall be u specified in the Third third schedule, and thi,e may bt Ul\fflded by the 1'-linbrttr from time to Scboduk ""''· 7. Can:asl!CII 11u11p(',l..1:ed or conb.ining biological l'Clliduea •" ,;vi~ susprcr by the ant.-mortcm and poe!mortem u.a.mi.na.ti.,n1111h.a.ll be n,-taincd by t,\C Cua, , Authori/W otricer and 11nall have a •·~~ined"' tag afl'iul;i, p;nding ~ ,-ii,1: or the laboratory ftl'Ultll, 8, (a) When: earca~ IU"C found to have biolttgic.l rCl'liduo in Cl(0Cll9 ortlte pcrmitwu t.>ler.-ni;:e level~ a .. •P«:l(i~ in the tnmi ,ichcd, UIC to the!lc Regulatio1111, they 11ha.\J be condemned and diA,x,,c,d of a- n,,qui~ hy th4> R""'1latillt1!1 undH thl! ltllpt'l"VlAlfln ... r lh<!!­ Autllorized Officer. (b) 1-lol..,. l'bue (() Where the biolop:al N!l'lidue in the i::an::-.-. ;. pt'Clletlt in an amount lMl tnan t~ tolera~ 11:vel a,"~ Ule cartlM may be:~ for hwnan conftumpti.on. (ii) Where the biological miiduc in the compoeit.e 111&111plc ii pmicmt in an amount of up to 10~~ orttM: tolc:n.oce 1eveJ """"' .. Laboratory Rei,ultl Wittldn.wal , ... Tld<d !ktwdu.lo Fin?i 5-dule £,prr'-.ital a1 ~J'(Cified, the carC&'L'I~ or meat ~hc~from may ho raAAOJ tor exro1 t 1.1:fthout te!>trk1ion. (iii) \\ here the bil'.'lo,::iNI residue in the i;ompositc sa np1e ii PteHCJ t in 11n amount of f1orn 11 to 19 ¾ of lhe tolcnuu.:c i,.-vel, all car..:a. !.IC/!. in the group of fivo hit be l'O--!ltaJTtp~ an,..' tel-1'.N. lMj~idui\lly and ()ll(. caNaMe& t1howin1 kvela of up to JO¾ may be Pil,'llled for c.-.port a~ in ({) •bove. (M Where the B;ological tc11idue in the composite sample j!j pt'l'!!SCnt ut 20"~ or srea.tcr than tlte \oleran<:e level, all ~t'C:l'1l<CI', shall be ,cla,ip\c4 al!' in (iii J ,111;,ovc. td Sarnlfla~e PfutlK' When the •nvestigatory pha-.c u dCM:1il:xid in par.graph 4 (c) {I) of tltedC R.egulatiorui, ha.\ 1tiown a fan,, tanch ot fctu\ot or &Q am l(t be fr..-: from pc<ticide PfQ<JJl,J'wi.. or to dvc oon­ t1ii-hlnt rcault.s of below I~~ t:ft.tc t...~ljrancc level• in f;he com­ w-~l~ ~ np1e, ln trircc C('n.'IOCuti\C t~t~, tne a11urui1t11 f•cm tl'IO 1cea. frtm, 1'Q!¾:h O\ t~\◊t l'.ha,\\ bet~ unda the ~nd or "urv<:illancc phw,e. (I) In t.tiK 11\ll'Vcillance pha'le, samplC!I «hall be taken u in tne i1m:1rt~b,lfY phl.,;le but at a r.lte of maµimwn one to twenty, (iO Wh':rc the 1a1;,ot,1t.n-y N$ults orthC!IC tests in (I) 11how lcvcld of biol.Jgkal ru1i,,u.1ei, in CM;f:11118 or ts¾ or t:h.e t.Jh::r.uicc kvdoJ t,1c f,mn (ee<llut. ranch or area 11hall to­ turn to t,tc fir.rt: or l1w<:?Jti:;atury oha"c until it ill c:l.:amd by t:IIJ'Ct: C0<'1>1e<:utiv~ ~ ii.<\ -A-~ir• :d in paragraph lb) abo\'e, 9. The Authorimf Officer 11hall control t'te U11C or pesticides in au• th;uit#>d f!>ftabll,.1~.b »mi 01A1.1l \,;.l-.i; .,:;,.pa tv .,...... .. ,1\ ~ i .. ~~01, of pn>hiUiW d1emicalM a.nd tue like for u11e in approwd establMunenta. Permil.W l)Clltick.let1 are 11uown in the fourt.i !ll:!h.eJuJe tel to• H.~0;111, 10. When. prcyhi.b1tcJ. (lf I\OIHl,Pt"ffl\'c4 'IU~tl,C\!11, arc fuw,d ln IU\ appto'>'e4 l.>'lt.1bli<Vu111:tl\, tnc Autuur~ ofl'll,;11;;1' 11111411 lll!:lkC provtllion for their mnoval anufQr dC"tructi"n. 11. When: animal., have been tre.ited with or e.,()08Cd to various dtup or r,c>ltkUlal, a. 1tufi'icic11t PfflOU or tilnc••••tne 11t1 called 111i.iitdrllwal timo­ llWI b¢ allov,o.l. belor,: K!,l(:h a11una.l~ are f)tel!Cr.tcd for 1da.ugl1tu, MO that an}' biological reitiiluc may be cllfllUIILtcd 4lr n:itll.lQCIJ to a-xcr,wi.:,Jc Je~l• a.'I ~ibcd by the keJt,!latiof\11 and All liNb:d in tt»e third &rid rITT:h 11Cnc,.u,de& to thcile Rcgulatiom, I:!. No animal that ha-, been e.-.pcriment.i.lly Cit~ to any J'lhanna· ce1.1tical. rhcmical or oioktgical proU\K.1 1101111 be accepted for 111Aughter at ar,r,oved CAab\il'.luncntll! unlC'll'I:~ (ol the M&11ager, l'l'llM'la1th worker and"~""°' or the eJtperiment Autimrt An a,t\'11nc:c t0 tllC Mulitlt:cf a11 enuuataon or tlks pl'\?OOCOl11 which dcmOnKtr..ite that the tme of the e.'tperi.mentnJ. Pf't)d.w.-t v.iU not f"t'f!Uit UI a.Julteration ot ~ meat or othtr~ W1fte t:.hey11hall i'lt1bmit the method• rot detection otthe te5idue• of lh• l"(O.J.ui:t ,ui.J it,: .,,,.,~hJraw~l r«lod. \b) Ol'I. a ba,;'11\ ot the •">ove mformation in /1;1) 't~ Mh,i11~r ~ha,)) inform the A1Jthoritcd Officer of the guidelines ror <:ontrol in each l:Jllle, (~ I lhe "'411\.1,uWI J>1em,.1ibe\.l in t'.n:: Rcgut..ti,;,<1• 4"" c.omr/iod 'With. 13. Ttte ,\.um!fter may at hi., di~iOl'l ban at te11ttict the tll!e' of """61.'ideit on rant\14, r.tlot>I, r.11leh'lfl and tl\c ltte 11.nd iJt RbbleR, t,ef?R, P()UltrY hollffCa or other llUCh plaC1::K wht:re anirrtal>1 arc kt.I"\, where 11uch l'o,'lil..~ octtslltute or may a l'V!t1tt1tc a iU-nger w ~ttn anll w,:11 hcl11g of UftCfUI anima.hi. and fill.rt, 14, The Miftilit.Je'r 11""1:ll fzom t!l'J:ll:! h ti.me l"(Jl\lC ~ or memora11da. lo( the ~i"111,r¼.-e "'f A.\ltl\l)l'i'>'OO Offic.:1"- 11\lowing the clicct'I Clf f'C'(tid<.lc <>n ani'Tlds. -n A.pft(.n1i~ l tcy thei;c Rel!u!11tion~, 11nd wt,1ch by on1C!' lnl.lY be •mended, from ti.mt.1o time. MADE by the Mini<rter o( He.,,lth. I.,a\xlur ~n(l Sr<,rt.'\ th.i"' 22nd da.y o( Ji1.m111ry, 198:I. E.LOOIO ARAGON ,'1'1i11iJ>.er vf lltaftli, fobour find Spt»'/J FIR.FT SCHEDULE LABOflATORY REQUEST FORM MINISTRY OF NATURAL RF.SOURCF.S 81-:Llztt C. A. VEt'EltllllARY MEAT INSPECTION Sl.!I\VICES FORM FOR REMITTANCE.OF MEAT SAMPLES FOR ANALYSIS Of' PESTICIDE AND BIOL()(llCAL RESIDUES &tabl11hment No: Quantity: ~­ ANALYSIS REQUESTED: IIIIJIIC(Or Wini taml)kl: No. or anitnals alaushl.Gnld: No. of 111imab nmplod: Lot No: -~--- "' Fann ot Orllb'I:. .......... TYPt or Ti1111t: 'IYIN or 1"1Clln1: Orpnoo;hl(mnoa Orpnopbosphata Oiethyhttlbestrol F11naicidol Dn,p ...... "'"" , 0--: --···-·-· .. --- - • fodlette IPl'dfic dru,or chcrni;als wboa .-..,, a..1, Cblon.mphrankoL au. ut laql\wr•-~---·"··· ---O•w ,ulmuu'li'd. -------'"-: LllbuN.loff lO whiell wnplfl .nt: Detillon ll'llde: si,,,,,,,,,., ""'' • n., lt.fffl'flM FJIUT SCHEDUU POkM 8 ('Ile, 4 (0 ) I.A80RATORY REl'OllT MINt!rT'RY OP NATURAL iESOURCES DEJ.lzt!,, C.A. vtTE,UNARY MEAT INSPECTION SEllVJCE RESULTS NO, Lot No. Sampje No, D1:e llerdffld Rn:eive.d s,. Typo of paelinJ Lab No. AuiJl\lld Sen! n,. 1'1111 Sent ,-· - ---- '!.'!!'"'" - - I I 0110A"'!"rn"""', 1 I I ! I ! I I I ! --1--·1 ' I I I ! ··--· I I I I ·····I·· --· . I I I I I I o~~,~-~Affl I Hflt,VT MFUU I ' I I I I ! I I I I ' I I I ·- - .. ·-· -· FUN01C1~ I I I I - I "~ I I I I I ),l(YT"P; Th,, fUIUl:I of lhaa ll'IAhwl, L .. IIXDl'CllflMI la DIIU ,, mlWon . SH.~Jm sct-1£DUL2 (ltq. 4 (fJ) S.\MPll!S FOil ANALYSIS., TIS~UES, AMOUNT .t HANDLING cw, ef' 11,, .... , 6/lbl'l'1"1tf AIIIOWlt Hiwlll"I .,.,,,. Cfilorin1le,,f Fresh Fat I lb/111JmaJ from '"""' U\o'fftoclr. ffydrQQll'~ :,f 1niln■Sl($ot ..... ., IM P('Ro. 0,- M"'• , .. " pbosph.ltell u,. ... • • • """""'"' ... I n, • • l,\'ll(lf, LU'llt t,...... m-'6 ',. • ......... . .. MVKlt, liver In, • • """" In,"' • - Flt, MIMtll liflOI, KIJoc,7 '., • """'"""" M1111elo A.1111tml; lffd, llVIII', tidDt1 I"'"' • • ffll!ttVP7, ~lfflium,, c.,:Emiuml Jtmnmorq-op eontcntt ..,. - • • "'- M- , .... • • - - 1 • M-~ J.011' For histoloa,cal eurnlnlUDR-Submit an t.bl'lormal tittoe:11 and the &OMW lilluel to l!Khtdo hart. H-.er, Udoff, tPkctt lnd !min (~m, -.:ibdh•m,, brain ftffll) tinllCSi to be fhlm l/4,. 10 1/2" 11 .;.k 11114 ~ b:1. 10"/4 INIT«N rottAatil!,,. THIRD SCHEDULE 11tra. .. • 1h 8101..001O,L PFSIDU.ts Of' J>F.StlCIDf!!. DI\U0S, ETC --s,M , 11.,,,.,, f11lnr,11u of Attlmo/ $ptd1!1 G11idf!//111! In ,.,.Ill, A PESTICIDES Alllrln IQlll Pl~1ann MUI: ~" Mll1' "n r.1 bub! do ,., o., All sre,:1n do .... o., E ...... hdJ,(l'elt bull 8enffl!e Heiac:hlo(idt (BftCJ f•t o., All•~ lh:11..-:hk>ro~ (HCB) .. , "' do Chlotdan• do o., do D.D.T. ~ Mm.l:IOlic. do , .• do Mill: 1.n Milkoin fi\\,uls Milk Producl1 1.2, da, on I'll bufJ . .., •. , fQH~l-frei= bui1 Endrlr, ... •. , All 1pecin Hrtitachlor 1.1\d Md.l.bolltel ... .. A1l 1t)l!ci¢I Met~bltn ... , .• c.tt>e. 111ttcp, scat. ..-lno Tonphene do 1.0 AUlplleie9 Mtn;,. •• M •• Slrobane do Dluroo M., t or t•t , .• do i>enhsM ..... , ,.o C.ttk,, .,iatt {I.I, t"ichl- l,.l-hi,, P ethylpbenyl dhlUN:) D.Japon Mot or flt ., C1Ule, thwp,, .-1"' Cu-bo(jbenoddon ... ,., C•ttle.ibeep.;oat. .wt• ~ ... <<" .. ~\) Mut orfa\ 0.1 c,1t1,. OW&. JWine. •'-" Ki~ or liver 1.0 C1tu&<.10•4....., IIWUNI Tltradifoo (Tedion) FP,-t, 00 All tpc:dn '-""""' Fat mNI , .• C..ltlc, ,o,.t. ,111 .... wiM mewl pmdUICI THIRD SCHEDla'LE {Rfl-6 & 11) DIOLO<.HCAL IU!SIDUES OF PESTICIDES l)RIJGS !ITC. C@urn•pbOll """"" wa1.1hion hn.1h.ioll Ronnd (fen,i;bwrpbOI) timw, tdibl<: Uuue,, or cu '" "' 11m1, Tlm.1<: rat do Ti~$" or rat Milk Fit, MN.t, Joru,lu,;t• ..... , ••• Tiw•{M=k. m<:al•\1)-produ,:OI Tiu.,..,,. r.i T~•ll<:t fat TiHUC, fat TiUUCI """' ... Fol Fat, meat mat pr<>d, .. a. .. M"t Fat, mut T<•lnattt:t ,,, A.n/tfla/ Sptdf'I G!iiddi'«'I /tt ,.,..I'll, 1.0 Ml 'llCt~ 1-0 Ca11tu, ""l""", •l""'P, SUU , .• SwfflC:. poullry ,., Cooked meat• 0.02 Cattt<:, 1hwep. iw-t. twittt 0.1 ..... (I.OS ~ ri l'.. ~"" b1fUJ Q.02 wt.QleMDk o., Calli•, cahu, --,, l(Wlla ~p " Catt1' cal"ell o,u C..U\ot,,~ .. , :n-p, .... to .....in., po.a.,. .,, All M ., ..... 4A C'•ttle,alwa,,..,.f(IMtl ,.. ..... 10.0 CtW.."1-.~INUI !A ·-,, C4tuc,1bcql ;,,j Catlk:,,at.,,IO!ll ••• ....... ., c,nJe.tlM,ep.... JwiN. ""''" TJ-Juu, SCJJEJ)OU (RrJ, 6 & 11) IIIOLOOICAL kESU)UES OF PESTICIDES. DJ.Uos, ETC. $uh1'ftllft ,,, , TDkNMI' or A.11l-l Spttltl G1lldtll11~ 111 ,.,./111. R.uelffl(, {tr,ifo,nJlc,) F•t. Tbt:11(! LO Ctttlo. thee\'!, ,0.1$,. md"" Wllulv mllt o.o, WhulcMll1'. Trichforf"u-- Cldibl11 tit1ue or (1l1 ., CutI .. 1f1Mp, PU, wfffl Methyl Plnlthion do • Diouthlon (Odna,) F,t ... c.Nle, ca1,.... ~. l(lllb,. , .. ;...,,11.,, DisulfotOl'l F•I F~- Ti11ue, r,t ., C.ttk, w-. poultry Pol~hl«in,tod , .. , .• All1peciel ll;pl,..,yl• (PCD'&) P1pmmyl b11101.ide Meat, f:Jt •. , CW-. pu., nine, .i.,p do , .• ~l . .:..-ten., TutU)'t ..,,.., .... Meal, f:1t ., C./lle, p,:,au., 1.wine, thcep ,. ... Chkkfflll\,~ 2,4-Dancl. :2.-4 DlehJ(,ropbtnol do u C.ttk, tot,U., fWffll, .... Kld"" M do l>anquat MW. Fat .. , .. ... ·- .. .. , .. Al•ddor .. . ., .. Propanil l,◄ dk:hloropbea,t - do . , .. MI.IOl'U Meat.F• •. , All-~l01am .. ., c:.nw.....i..-..... 11-v u- .., .. K- , .. .. fHIIW SCHEDVLB IUOLOOIC>.I. RESIDUES OF PUTICIDl::.S, DRIJO!, ETC. ,.. , TW•n T1>kN,.,.. '11' .c111,,,,,t s~, GMl1!tll'1N' flll p.p,wi. Mm, fat o.o, Poultry M...,. , Meat, Fat O.Ol Cattle, tbt-t'p, aoau, •witte oi,- Kld!W1, liwr o., AU 1pedel (>I PRUGS OENEllAL °"""~ u ... ,., CalUe, ca.I~ lhNP, IQ1itl MldiC'la •. , ..... "'"""' , .• Cattk,.INtll.• '"""' u.o ....... , ,, . ...... ,, ,., ... ..,, - Mutcle .. Cattkl,ilboop,IO&\t.tWIM NIWf~ .. ••• ... . ...... fdlblel.lUOI , .• Cludulld, CUlle ,l<e)etal ,,Hnc:le .. •• M ,.. M- '·" ""'" ~ e4ibNI'. .., .. , ..... bobcirudim ffCL Fa '"' 0,-M- u .. Thi■t...tuoa. -- ~· c.tt'-, twine lhoep, 80m ~ .. !'<flft<.'tt.lo.,id,:, .. "·' ('.'~ .......... 1 ............ '" DR.UOS-SULPHONAMIDU Wpb~ P)Tiduinrt -- •. , "'"" .. .. ..... -- ... "' .,. ...,.. lulphtda.l~ .. u Ccmo.~tlll'UJ,ddcba ... .. .. °"""' THIRD SCHP.DVLE ~ f ,I II) BIOLOOICAL RE!llDUES OF PF.STIC1DES. Dl't.UOS. ETC. ----·--··~· .Sul pt>iunethui roe S..ti,""'4~~, ... Sulpht.nwruine Sulphalhiuol, Sulpbaquino11aJin, Sulphabrom~no SUlphamethiuok, $ulpbanilami<Y lnlphdm)'•l" Tu.t1ttJ do .. do do do do Edlbltliduril .. ,. TaW'l'OJltf • G11/Mllu Iii p.p.-. •. , Cmkl, twiao N.8, T~ "'4d"4 Pftla' llla-n (M 1)Jlffl lffl ~ peimit\04 in 1t11 tWfl1:imwtild4 d:nao (,I) DRVOS ANTIBIOTIC$ Ampkillin Mutcle, liffl', lldrie,- 0.01 Cattle, IWUII ........ M-i-. li.,..., ~ ... ~ ... do ... ,....,. do M ·---Strept0mydn do M Swine. c::bktem. ~ do Cott!, do do ..,, ""--......,. ...... ,. 0.2, Cllttki. IOll.tt .,, ..... M\1'11.lc., tiff10 Q.1 c.ui., ....... ...... 1tidb11 FIil nllllD SCHEDlJl.B (lle,s. 6 A II) BIOLOOICA.L IU!SIOUES OF l'ESTlCIOl:'4, o~u,:1111, e'f'C', ----------- ·--------~- ~ Tb1w1 T"-<, ~ A11I-' -~M't G111tM/ltt' /11 ,,,.,l'Jt, 0-~ Sulplwtll llt\1$Cle, livet, ki®t)r •. , T.,..,. M ••• C■uJc, ••h• u- ~, Sl)r,ep, dllc:kcin1 """'' 0,1 u,,,,,,,,a, ltid~ 0.1 Swl!le. chkkens •• C.tdo, tboep, Soltlo hl1bn t.f•le. Jiw:r 0,1 C,,ttlo, QI-. 'Jwml t:'at, liffl', ~ 1.0 C,,"biekcma. tudtj•• •li~ """"' ~, c,111e, w""- . .. ].0 Ouck-. tarkieyt MUl!de, lm:r, kid-, ~I °'"" ... ••• .., u c.1-.™M,.-lt,y u.. ... .,., u- ,.. ..... ... u . .... u ... ... ....., """"' ... .,. , Dih,d.Olbeptouqdti odfbWlmmll o.o ., """" ...... --Macko liwr, ~ t>.J ·-.. 0.12> -.. ... .,..,., - .. '"' c,l,m THIRD $CHEDULB (Rea. 6 & It) BIOLOGICAL ltESIOUES OF PESTICIDES. DP.VOS. ETC, $,d,,r/dlttt TIUW.i Talfflt1ttt 11/ G11/tkliM 1111 ,,,,WI, Clo:w:IUin edible tiUllfl 0.01 ffJp-uin,-:in b ,o ••• u.i(l"on do ~, ,., DRUGS HORMONES• tlit1h:,l1tilt-om1.t0I Muxle,llvt'I' 0,0 ,..,. . MVll(:lc. liYCJ, kidney ,. , ZnnJenone• • Dionocsttol diaoetato Eatradiol moooa,ahn.ltate Edible twuo .. 1-f~tfot and Ol.hcn &tndiol Dffizolbl .......... M Melettamtrol Aecll.1- do .. ,, ... ... ....... .. 0.0 --- do Oh '"Towtllnoe lcwlt ror horrao:1M ute;I in liV01tock and poullr, it n,o OA -a.111 ...... ...-,:lo • ...,1nu,,.....,.,. .. l.<>k-,;•- lc•..t AlM.bfhl..t U,w ,.. .. ,., Ml.!llt.16 .. , do •• Uffl, Wne, Li'l'ff, 'ddne, • • ··-~.!i Aitlltldl S~/fl C.ttk ~Wine, p(l\llll')' Cattle C.llle, 1'-P, ,o.b .. '°"'"' netren.....,. ...,.. c.nt, 1'10eftrt, 1-.nt,,, c.«lo." Cattki (heii!enJ S'll'itlr,. chkbnt\, 1'afbyl c.nt, en"' ... ... , .. • • • • • • .. F01,l,t.TH SCHEDULE (Rtt- '> Pl!STICIDES PVltMlTTED FOR TUE USE ON ANIMALS AND ON FARMS -- ··- l'rfflllhrt TIIU,a-,,'" Tu1,i.r1 Gtt1*11,,,,pi p.p,WI l).IJ,I, N• OIIIY ror , .. "' Muc.q.11-ito ®""" a,......, N• only ror O.l All li<mlef; -~ tcor>I .... Did4riQ No Yn .., Undmo No Yo , .• ... .. !twl-r.t nr nlnt .. -« No Yo ,~ ... Toupr- No Ym , .• , .. Clodri• Ym y., All tmMt """"•""' Yd Ya 1,0 Mml A ,,.. producu """"' . ..,, Ya d?O Fat (&beep Olll)-) ""w- v. v. ,., "'""" ... -. ..... .... """- y,. No \.0 -., .. Maulthlon Ym Yo ... Ma&..sat~ Jiialed (Dibtom) No Yn M, ..... .......... No S'"1111 lfflly ••• All... ..... Y• y,. ••• .. ... T-• No Vm M An Qtpbenylamlnt Ya (Kffll'> ·•worm l'#POUIIIO N• AD..,, - Y• y., ... Ca ..... flfTH SCHEPUl,:f!, WnHrHtAWAL TIMES (l\tt, II) S"'11ttU11tt Spuln Form Uud iw//1,Jl'Q"""' (b,f-,.,,,,.., Ruel- Cattle lldaya ll;nnlM\ 'B«t C.We l,\.Tl!>":n m tn.l ld mixtuft! per 100 lbill Nl<I)' -gbl for lof .... 0,6% (ffllmi,i. Pf'(' 100 lbs for 7 dlYt 60 &t1y, n.o ll'J/JOO lbM Ii~ ...... wrilltl'llonllY LS"~ mincnl l\lpple ffiffll block Jn,11\.llN l.!1%, oil bKt rubber ...... 0,75 Dip otlpra)' ,. .. ,. , l'I"~ Wnrm lf'HI.I• 1.1.t.:,,i -· $JJ% Dim " -Shoop &Offt o.,~.~ Dip l)f' lfll'l)' .... ,. ,.<r;. --trtatfflffll 21 tk)'II ..... 0~ Dip ot 'l)RJ' ,,..,. S.O"~ ~ .wm lnat· mml ,...,. Owl= Sheep & Goat 0.0l-006¾ in water ...... Ul¾ Dult """"'''°' Clltlt Sl'leep A No ra:tr1ct1on1 o~• O.Z,°¼ Wal<"!' ...... ,.,M No 11111l'ir;tiOM , .. ,. H~lnllOOII ·- ,..,. or in eomt>inatlon1 (lllortetracyelfne Swino 400 ..,.m fi,r 14 day .. ..,. --· ~-l'wn,cillin and SulrJI• ... M d,1,.. <"•11"' 1cn .... 11M- ..... 1",,lc,mn and H-M ·- ,..,. ... bllnt """" , . ..,. APPENDIX EFFECTS OF rtSTICIDES ON AN!~ AI.S ,-id&,l may be grouped u chlorinated hydrocarbot11, ~ otpnOt)hol,­ 'Phata. fungkidffl. Mbie\d.:i:&, hn:vy met.alt., "C.tc. J. Qlotulat.-4 H~ ~ compuunds &re t1.tored in the rat of livestock and r,oultry and •ct W l/llimtil.:i.nW ot derl'CMarlts or the icemral ncrv,n.m ~. with nt'\lmmu~larsymptomll wh.ieh usually appear u ~UC111!11'!e811, mut1Culiu-- -1,ra.sn,11,. 1.Kk or cc-ordination while ..-al king a<'ld C(t11vu1~ 11itmi.. Thi, !liJnptom1 vuy ac«irdin1 \.o U1ID upoeun= dOIIC and tile nltUR of CIIC a,m.,. ruineiplc of the product Wltd. (A) AattfflQffl:111 STffl,PlOl'D$ (I) R~I~, anorexia. l"(llywia., abnormal J!Oflt'Ures, aallvatinn, tnuseular spasnva. Cnmlbli.ng, Mhh'fflng, ~tdT and ~-er.Ltcd pit, 000\'Ul.lliOI\I\, depn:l!SiOtlB and coma. The m".lnrity . .r a.n,m"'" fl,l w Ryrr,('tt)m, v.it'1in the fiM 14 hnuffl folln"OnJ .,.,.,............, bvt ill acute ca."IC!f. the anUIWII rnay appear highly ~ or in a camato&e titat,e leYcnd houn before death. (Ii) Pcultry N.,..,cous ~hi..,,, h~cit.al-ility, d),ar,:,Ooft, t1"t'!'m0nl., convukwnJI a,:i4 ~,.,. Mucou1t, n.a.-.al dj,4ehar)'('. Atrorhk, cyanotic comb and watt1e11. (8) po,t morttm dt:a1'tff (/) Li~r$ttXk Ccngt'4Jtion of o~ 1lungoi. liver, kidne'}'!!,) lung oedt'JIUL, haemon-haga on epi.. ea,rdium, btoo<l~ti;1g,ed froth in tlte tr ~hca and bron1,:hi., conQC!!(ion and oedema oft' , bf&in ltJ1d 11pinal cord, ~ cnt~ili..~ l.\l\'!1' or.\l 11\i;e,ition.J Oegenntion or ()l'ga"ll'l (in chronic ~i. In ar.imal!\ "hich 11ho\\ !\ipl!\ of aci.te roiiior,ing the &ymptotnB, ate non gpccific, J?'"l!''(llly 111 u.ir,g l""(l:!ChiA:I hllo!!11'\0rr~ in t.hl'! 1-rt and in ~ Mj.;i,:ffl,t to th,1-~ blood "'e,111ell, (ii) pqu/lf'Y Arnber nuid in pericarrii.al iw:, enl&rrm heart ••ith di'ltOrt,:.d roronary VM1¢1i,, Ol:ffl~n of tho li."411' a.n.d k.W,M~1. Oo~•a.t-,;,..1, Q( Ul4 ~ linf.\\g-, ~WM' QI;~ dtym'-, a.,dtdl. (C) ubont....,. Encn (1) Chemical - Submit J poll!ld of fat. fn.m:Q (U) Hilltopathologie&l - submit all abnormal tiMla and the n,~nnaJ tlssue9 which •hlll tneluJe JM:&rt. liVd, 1pJecn. kidney, brain (cerebrurll,.cm:bcllwn, medulla and brainliem), $1.utpkt, !lh"uld be fonn 1/4" tc, 1/2" thk:k and~ in 10% buf1'ered fomwio. 2. °'~"' and C'..ldMmatet Orpnopho.phatca contain the pho!iphoroUI radbl in a combination whicli tnablo, &be rompound to inhibi' the iled)'("hoUne:t1ttrue •lid other MOlinoll~ cartmnac. (ITIMY of wh.idt ha\.l a l)Clticlde action, 1.ct in a aimil.u' manner to thu. o( the organoptw.,. phatm aa pt.ra.'t)'mpath,icomet.ic ~ that inhitit cholinC!l\ent/lC'JI. In WI' t'WIC tho inhibi .. ti'ffl talr11111. pllll"'!I dUI!' tn eart.mylatlon iNrt.ead or J>h<t-~J&tiotw, (of orp,M)phmJ'huce) but tho dl'«;t, are limalar. Tho biolop::al action nl9Ult1 t'ffll'l'I an Cl:1lalll5 or acetylchctlinc at tM nene ffldinp where &hey Cww;:tion .. bnllmiitms o( the nerve:a impu,be&. The IICCUJllulatior, of ~tdchtoline lek1a Fint to • .timulation and tater a para1ym or 111 Ml"ffll lfn&Na and motar endiftt'I acept the eodiop or ii. sympad:,etic nm-e fibnll. •n analytb.i method~ ror the ~on or all orpnoph.mphatM but the inspedor should. if l')OIVl,,iblc 11epdfy the particular orpoopltoaphate U' aid the laboratory in 1Mki•1g tm chl"mi1..11I detenntnat1on on me t!Jil\U-O kllbm.tued. A commonly U8ed carbaMale la 11Cv1n (oa,.,,.,.,i), c'• AaletllllOftffli s,...,.... (i) Linst~k Salivation. d)'llprioe,q,. n:stlCllflflCJf\ fllilTnc:i,e. abdominal pa.in. diarrhoea,, oonvuJ,, ..,,,,, (8) PMt Mman c:a..,e. Ju IICUlc' pulsunlng I.hi: ICNIOM an, never pathugnomk Of" particuiarty oottaable. Haemorrhapi are oet1¢'1"Ved in th, ltearl. Junp, and ga.,tro-imtffltinal ~ Puln1onat')' con-on with aigns or oedema and pnrumonia. ,'\ccumuJation or muctll in thlJ broo(:hJ. Poultry 111how a dark conpJtcd. heart and, injecta:l subl;t.l\aneo11& Wlllela, (C) , . ~ Eu.,.. .Mlli (I) CJ,,mk:41 Organoph(Wsphak!i I pound each or mUBCle and liver Ou-bant3.k-A I potmd ~ of fat, liver and nlll$C!c to be submitcc:d (roi:,cn. (ll) Hinopa11tofurtcal M for chlorinated hydrocarbons MIii (1((0;(11) 3 ·-... ~ are frcqtaentlY 11/ttd ror treatit1111Ct'l11 IIJ1l,i.nll whkll laf.el' ma, IOl'l'.ICtimea be ulcd for animal feeds. Such a practice i, eorttiddcd to be uniiafe since tolcradoe, have no( been --.bJi,,,hed for biolopcal l'C'Mduea for n\OIC or thdl) cornpoundll.. There ill'. ·10 eostab­ lillhed. mi:thod for IICT'eCn.U1g hence the inllpertor ahould specify the furtgic:id,c to be anaJ.yaed for, Commonly u9Cld fingicide are captain, thlram. cer'Clllllt and zineb. (A)--S (Q Nu.al diilcharae, colic, WUThoaa, 11tili'::d p,it n.pid ~ clcprcllioQ and ...... (U) ,., ,,.., Stilt,!,d pit. •lil"f"9d tmdon, •pt"IUl"I toot, eni..r,.d ~ <wtMI or «oabd too.. Wleltr.l ~bl:ncy, 11,nonnal cutvatllff! of femur and tibio-t&tBua. (8) - M-c::io (1) u~xt«k 5ympwfflll are non-«pcdfie. Blood unaeo fhlid in abdOnunal and tboracic cavitiea. Liver and kklntya dcpncnttd. 1-lacmorrha{• ii: h.i lunp and p1tro. in~ linallnl<I. (11) ,,, Spa;itk tOT di<: compound Wk>d. (C) .....,.....,., E-4• (0 Chnnir:ol One pound each of trCllth liver, mmcle. kidney, and ru eubmitted frozen. (Ii) Histoputl,o/ogiral M for organopho:1rhate1 Sec It(') (ii) 4. Httblddd Herbkirlbl and other chemical11 are o~ to control undeflirable rlant'l. HorTl'Qflie,. type fierH,;id~ tun't added ft" the li.~t of or?~ ic anl! inorganic produci.9 l!!led. The herbia cided irn:ludc dinitnxompour,ds, chlorobenzok at:id!I, An.et\1Calll, phonol11 llOd hormone """'· IA) AnlfflUM1ffll Symptorn11 (f) Li~l'SWt:k (ii) Pcm/try Oerrci1,,ion, anorexia and mu"!Cular v.-cak.nCAA,. tD} Ptwt MnrtMD (bmtfl"II (i) J iwmocl;. Non '4p«"i(ic, 11ndi~ted recx1, ia'ltm-inte•ll11al tract with ulCf:'Oi and necrotic ro-::i., inrlamm.J.lion of lh·cr, kidney and luns,t, <iii P"ultq i,.pn:ific for compour.Wl- WICd ,Cl Laboratory Euinloatlon lf I (hrm1r11I One pound each of fat and mu>!Ck eubmittcd fro1en (ii} }f,:J11,p11fl111/nl{kal A• t..ir orgMopk<,,,phatol!, s .. l(C) (ii) 5, Ha•:, Mfflls The rn<1'4t coJTUnorly occurrir• ur the hea'I) n-c-ta11 arr art1Cnic, leaoi, selenium alld r,~ri.-..>')' ;\..,....,;., .,,ay be nl-.tall'IC'Xi from ne.wciclcl. hetbK:i~ or comoouradll. \\itn ,,odium copper and Jca,I; it~"""- 111 Utt !!Oil for loog periOd&. lead, it.1 aJl,~)'!l aNt llalt.-1 frequently prod~ l'<)i-;oning i.n caule. The JTUt,in 'IOull.'C8 are pai,1t-., pci,!Licid~ wt:t a:11» ba<~!ffll (a~rnobllc:I. &1c:r.ium n.11.y C(lfl".C from in:ieetiddtff and in ~ &rea'\ from the mil, \ltakr and planl" to~t.am1ng ~ic::niurT.. Mercury ii\ a .;umu1all\1: poi.Ion .-rid ma,• be found i.n l\lf'sJ.;iWI'!-, -.nti'"'!'l't""' al'd t'(lffnlliVI" "~1b)(nw.U (~ e~\,:iride). Tlw,,e ii. no ~in3le m¢fiod of indtiillfication of hcllvy rnclal!l thcrefon: il»:: imped.or 11bouid AJ)mfy whlc:h nte\al!l art to tie detected, (I) , ellk { Al AMaaonnn Symptoun (Ii U,rst,x-k hJ.iqtion, \bri.,t, vorr1i~1, ml,l!l,f;:le twitchin1,tremors, uaennJ ,-rt. colic, diar­ rhoea (humorrhqic\ J)IU'al)'&ia, C()rna, (U) Pooltry Araenic:at. tan be ll&tdy 111td in toed ror poultry ta.Pied tor tood r--odur:tioo whffl vllrld in~ with ~tis~ do--.,es afld wi&hdra.... . ~ Rciatlml, •pa.'lfflOdi: fcd1t11 of Ctte neck and '- of cquilibriwtt. dqtawd ~ (B) P081 MortftD Outnges u .... , Haemorrhagic ga,~-enteritllJ, inWl-tiMI oedema. mfl:vntniU.lon and u·'""-· 1?11 of (ii) /¼ulrr:, SumnucO!'lal crop and gi.zzlµ-d inna.mmation, cat:arrhal ent'Tltis. ~ kidney \1t­ generation. (C) Laborate'lt)' Eumlntlion (() r,,,,mJ,-,1/ One pound caclt of frcwh fat,, liver, ,nut1Cic, kidney, rumen or cropcontcntll, sutt.. mittcd frozen. (ii) Histopatlu:il(Jfimf AA f-.,r orpnopho,ph.w.e, see l(C) (ii) (2) , ... (A) Antemortem Symptnms \I) lh'l!Stack (a) Acut~ Depn,<t'lion, J:nl.lSl:Ular weaknca., U'lliine: it, ci,:'ch, htad .aQirw&. Oh~ pani.ly,riM of m&-.id:tiJ m 1,ict1.J=-'r twit.:.,ing. griniling o[ to!,IJl. bellowini;. vomit.in& Ji.atthOla,, b1indne«, corivuJIUOM. (hJ Chronk:-Anomi.a, d-:Pf"--IIIIOrt. comtii,a.tion.. mu..,cular weak.new. ,.rotttratimi. bri•ket and leg oedema. (ii) pq, .,,,., Anorexia, emaciation, pol~·dipsia, mUilC'Ular weakntt.", drooptn, 'l'ingfl,, grccnillh r...-. (8) ..... M.....,0.­ V' U"'ll«k (a) AClltt HamK)trhagic ga.'ltro-enkriti", pale and degenerated liver with llC!Ct'Oli.c ~ •ub erAl'dial hacmorthag('tt, (b) Chronic: yellow liver with lobuki ctegenmtion. IICattem:l hacrnorrhagm in ticl,, ncys, heart, •trophy or laryngeal mu.,cJei, (honlcs), kidney ~ (ii) Poultry Ht'j)RUC &nd renal ~. cnlmb'\ hepatic and cardlac R'Opby, hydrol)CI'~ cardium. pH bladder hypertrophy. Ura.te,. in kidneys; grm-ti"h~brown colound gi.mvd M"'°"" (C) I.AbontorfEumlatloa (0 Cltmliail Ono pound eadt or fresh rat. liver, kidney, mUt1Cle. rumen or crop contmtasut>­ mitted rrozcn. (II) HlJtnttatltollWIMI A.a ror orp,rt0-ph~r .J&tca 11C1C l(c){lf) ,. },lim:111')! (A) Allttfflolh!rn Symptofflll (/) Limtock (a) Acute.,: Vomiting. bloody diarrhoea, pol~ •.&ria, i.ncrtU d respimion,, "'hock. (h) Chronic: Wcakne&'l., dept'C!l,ion. incoordinalion, m•)~cle apa.'Jl.'\tl, poi,tcrior panv lY'lln. Mll!I.Cff\i4., a .. o~"Ml.o dia.rTfatt.-, polyurl-. &th1ria. blind-. (ii) Poultry loooordination and progm1Hive muscular wcaknot1, d<:prC!5Sion, diarrhoea. {BJ l"Ostmm'tffll UWlltt (i) Li'Vf'.ttock (a) Acute; Mhgrey mt.lCOtia of mouth, tongue. pharynx, OCHOpha.gu•, (~ adiOfl) uk:etft of ICl'L'ltt'O-int"'tinal tract: hat:morrhap i.n nooe, lung,\ kidney,i, liver, aubpetitol'ICIU tiasuCK, dark red blood with slow i;oag-,dation. (b) ('hronlc; Pale org:aivt. u.l<:er11 in p'ltn,:,,,int:'11,tin:,,I tract, necrotic and haemorrhagic an.. in liver, nepltriti~ gplenitiot, (Ii) P1111ltry Gray area" in mouth and OCM1'ha,U!\ catarrhal inflamrnation and ,,ecro1ds and 111,,ughin[I: of muC01:1 of r,rovt11t"k-ulu-t aol 1nt':flti.ne, pale kidney v.ith. while fod. Fatty degeneration of 11\tt, grccni,h fluid in tne 13,'!tro intestinal tract and abdominal <:avily. (C) laboratory E:umiaatlon (i} Chem/cul One pound each of frei<h rat. m11,11dc, liver, kidney, rumen or crop .:oritents ~b· rnittt<d fm7MI (ii) 1/i:rmpothologkal AR for organophoilphaeoi l'leC 1 (C) (ii) ,4, Sdcl'lhlm Into,ication l't!'lu.11.!1 rmm ~efl or fmm 111tlcnifmu,111110il (Alkali J>iffealle) in mtain um" or planlll or water from MU.Ch 110i111 (A) Aet- S,m ...... ( I) Lirntork (a) Acute: (Blind StaWf'I\) Labourtd breath.ins. l¢lllerina. dilated popilil., pan.!y.. •iii o( throat and rongue, pro-stration. (bJ Chwnk: (Aluli. t>~) Lt,ro,:1-, ,;rM;l,,c;d ~, joint nWTIIICIIII., bit.u- lo.,,. ,cm. anciation. (B)POltlliofmD~ (I) I..Jrt#t«k (ol Acute: ColtJCl'tion ot luna1, epic&rdial ~ oonption and ukeration or omuum. (b) Chronic: Articu1-r 11urf.-cc,i, or tonr: bones wtlh aoeions, hear1 ain,phy. lim­ cltthooi,, (Cl .l..aborator, F.u1,1dn1tl0Ji (I) ('J,<'>'nlMI Ono pound each or rl'Cfth fat mw,clc. lh • ki· ..-y, rum ·o or crop eontclW:I 1Jub­ milt'm. frozen. (ii) Hf,.wparholof{cal At, £or OtganO phoapha.t~ $CC J(C) (ii) 6. Potmtlal Drul ResW1tt l tibioticil a"d other drug, arc caua.lly ull,(llj for the pre\-ention and trca.tmc11t or di­ ,um,..,. ~.•tt'I(' '1ru8" u.....i n " r.m ,ul,titi-· h<'lrtnlll'lffl, tranqui!Ulel'll,. anlnt!lm,nti<',fl, anti, bi,,lK'f' tlC. 1k rv.:;., U!k:fu: purl"()lle onl;I' when properly UllCd. lnJiiCflminaLc WIC of anti.bl<). ti.::it anJ./..,r drug1 ,,1 f,,ed of hVtwtoi;:k pou't.ry. or direct injectton. to prvmotc sro~th ot an~ i.i a lrq;ut it C3llll<! ,,f can,::er. Druga nuy ffiilllk lh, 1gn~ of d~ and such ani• malet may be uil:Juit.J.blc for food purpollll8. The IMpcdor mu$t be on thc look-ou, for tllOkl -~ ( .\) Aatemorteva S:,mp1oms Swe•lin1 in the gluteal or other heavy muscle rcgioos, discolourations in the n:,aion of botJy or.f1cm, pronounced mcuicin..l er ,1>(:11•1cal ooovr a.,,1 other al;11oriJ1.U IUIOwd i,. lou~od r ... r 1n U.. a.nt<.-:n1.:>1 i..-,,1 iri-i--t,nn... B l'Olt MCll'tem ~ 1 ea.ona in the ltll.llM!kH., dillcolouratio, o( the llt:bcutan®Ull UMue. and ch.uactuu.Uc J]ICWC,RiLI, chemK:al or ol.,ilCI' foreign o..lout8 are pv,1.'llolll ~ fi.ndinas,, M~ ,.;v, ........ ~idu,,;;;a, Theo l<\l>f"",tor Wto:tuld be- t..'1.• IJ»k-01d r»r p.,1o,i,1b lu.i.>M""" 1,-,:t ,...,. jei.;tion of antibiotic:S etc. 1·1tate may be in the heavy mu9-;lt mas..- .... ~ In the. ;orm or an oily vi.'ICUU8 Upa.j4<l ycll(l'lll ftlAAerW .,..hkh on kl.borat,ny u.YY h,wo IW.->~D t.c.-apc1,1ti,,;: lctYcla or u.rup. Tnmmirg of tlttclt area.1 doe~ ML ai.'lun. that ti10 r.:•t .,,. t.1;1 c.1.ria,u will ue free of 1uch rct1-iJUOl. ~ carca""1 ,1:1owin1 lc,lfon11 of in;c.:tioii 11,101,I.IJ be! rct»rloJ a.nJ di:1.,oJCd of in 1aM;ordo.m;<e with t.hc li.l.boratory firi~ (C) Labora1orJ ~mlnalka (I) Ctwmkal OM pound ~h nf inji!,clinn aite, normal muscle. liver and kidney submitud fMml'L (U) H&topotlwlotkol AA for orga.noph.Olphato,1, see t (C) (Ii) (iii) ln ordt:r to reduce the J)Oifflibilit.Y or error, in tbe.uuy IU1d W Aid th-e tr.tc:in£ of Ml' antibiotic or ot,ict drull' i 1jedions, all a,ailaUe informationa rcz;ardina: ti»e ca.1= snoutd ac,.. ,;Qlll.Pf.nY tile w.borat,.1ry 11.1,mplc: .i. antemortem sympiorna,, ori;in of~ nwnbct an ,Gt number or an.ima1il atrcckd, aolitiotil. i..-pected. doae, manufai.:ru:n:,, produd name «c:. Gani: Flkcu of pe11tlddn ill 111111 Tho prod.1.M.11 of dep-adation of antiblotice and t!-:ar metabolitiel M well• the anti,, bioUC:. lhcln.:1- c.m eolllllitv.\.# & dAns« M they arc a.pabkl of l«!Sit.illin¥, pc,oplo. e-&, pcnicililn JII dq;r,~ 1nw protc61l combination~ ••it:1 po,iicillic acid. Only amall amounu are n.,cdod to acmtitillc! peortc, Ar-rt from thi8,, t11e11C ICl'lliliaing sublt.anccll, .-hen taken in wlth rood UA ~wwi .J111t· 1 ... 11..1~11.r.~e in hi:kri1\ ;., ttw,, h'l(Mtinal tl'lll't Son antiblotic:s such as th(: tetracycline an: deatro)'Cld. on «klkinJ but othm •uch u Afff1'1tomyein aro oot de11ttoyffl t? t1,."ly 11ignificant cxtt1.1L Frtitlil'IA tm no effect on antibiotic ~ ChJoiamJ'hcnicol ~t.Tatc:,i. i.n 1ho ~ mattow ..au/Jin1 a teticulo,;y1ope11iL &da::nucaDhaemo&iobin and an in.:n:ueffll.n.mm •hie btoodacruntudothc:rabnonnaliU.. Tett'.l,cyctinee favoµr liver toxicitY, intnf'ffl! wilh toot.h derelopment In the 1.-.ctua and kidney fa.iii.are. S~ aotibiotks of the! aminogluoosi>Jc c,:'OUI'.' may caUM ni,uu,mUIICul.at ptU1,ly11il at1d impairment of hearing, (.."hlorinaltled, ~n11 ~ticldel .. 4.'f CIUt ~ datl'lllp: tt'I the peripheral a..d central Ml'\'OII!, ayw.tems, raffle the 1evd <tf a. • ~ and \i..orpnifle \he biof"yntheaia or ~d thu~ produr.-lng c,lllt,ee.