Ministerial Joint Decree No. 73/2005 amending the provisions of article 36 of the Food Code, in compliance with Commission Directive 2003/95/EC amending Directive 96/77/EC laying down specific purity criteria on food additives other than colours and sweeteners

E<bHtv1EPII THI EMHNIKHI ~HMOKPATIAI TEYXOI .dEYTEPO nEPIEXOMENA AnO<l>AIEII T ponono(riori Tou 6p8pou 36 Tou Kwci1Ka T pocp(µwv oe evapµ6v1ori npoc; TrJV Ociriy(a 2003/95/E. K. TrJC: Em­ Tpom']c; (L 283/31. 1 0 .2003) yIa TrJV Tponono(riori Tl']c; Ociriy(ac; 96/77/E.K. nep( 8wn(oewc; 8Lc5LKWV KpLTrJp(wv Ka8ap6TrJTOC: y1a TO np6o8na Tpocp(µwv TIA.l']V TWV XPWOTLKWV KOL TWV YAUKOVTLKWV U/1.WV. .. . 2 10699 E<l>HMEPII THI KYBEPNHIEOI (TEYXOI ~EYTEPO) 10701 ~~-~ ~ Tpononofriori TOU 6.p8pou 36 TOU Kwc51Ka Tpocp(µwv oe evapµ6v1ari npoc; TJ"]V OcSriy[a 2003/95/E.K. TJ"]c; Em­ Tpon17c; (L 283/31. 10 .2003) y1a TJ"]V Tpononofriori TJ"]c; OcSJ"]yfac; 96/77 /E. K. nep[ Swn(oewc; e1c51Kwv KPLTJ"]p(wv Ka8ap6TJ"]TOc; y1a TO np6o8£TO Tpocp(µwv nAJ"]V TWV XPWOTIKWV KOL TWV YAUKQVTIKWV UAWV. 0 vnovPrOI KAI O Y<l>YnOYPrOI OIKONOMIAI KAI OIKONOMIKnN 'ExoVTac; un6l!Jri: 1. To tyypacpo TJ"]c; t.1eu8uvoric; Tpocpfµwv Tou 1ev1Kou Xriµe(ou TOU Kp6:TOuc; ap18. 373/2005. 2. Ttc; c5LOT0.S£Lc; TOU 6.p8pou 1 (nap. 1, 2 KOL 3) TOU V. 1338/1983 «Ecpapµoy17 TOU KOLVOTIKOU ilLKOIOU» (<J:>.E.K. 34/A/1983) 6nwc; Tponono1178J"]K£ an6 TO 6.p8po 6 TOU V. 1440/1984 «Iuµµ£TOX'7 TJ"]c; EM6.c5oc; OTO Kecp6:AOLO, OTO ano8eµm1K6. KOL OT1c; npopMljJe1c; TJ"]c; Eupwna'iK17c; Tp6.­ nei;ac; EnevMoewv, OTO Kecp6.AOLO TJ"]c; Eupwna'iK17c; Km­ v6TJ"]Toc; Av8paKoc; KmX6.t..upoc; KOL Tou Opyav1aµou Ecpo­ c51aoµou EYPATOM» (<J:>.E.K. 70/A/1984) Ka8wc; KOL TO 6:p8po 65TOU V. 1892/1990 (<J:>.E.K. 101/A/1990). 3. To ec56.cp10 15 TJ"]c; nap. 8 TOU 6.p8pou 6 TOU v6µou 4328/1929 (<J:>.E.K. 272/A/1929) «nep( OUOT0:0£Wc; 1£VIKOU Xriµdou Tou Kp6.TOuc;», 6nwc; aVT1KmaOT6.8J"]K£ an6 TJ"]V nap6:ypacpo 6 TOU 6:p8pou 11 TOU v6µou 2343/1995, (<J:>.E.K. 211/A/11.10.1995). 4. To 6.p8po 4 Tou t.1m6.yµmoc; n1c; 31J"]c; OKTwpp(ou 1929 «nep( KQVOVLOµOU TJ"]c; A£1TOUpy(ac; KOL TWV epyaOLWV TOU AVWTOTOU XJ"]µLKOU i:uµpOU/1.LOU» (<J:>.E.K. 391/A/1929). 5. To 6.p8po 1 TOU v6µou 115/1975 «nep( Tpononm17oewc; c51m6.s£WVTIVWVTOUV. 4328/1929» (<J:>.E.K. 172/A/1975). 6. T17v un' apL8µ. 1078204/927 /0006 A/6.8. 1992 an6cpa­ ori «nep1op10µ6c; 2uMoy1Kwv Opy6.vwv TOu Ynoupye(ou 01Kovoµ1Kwv» Twv Ynoupywv npoec5pfac; KOL 01Kovoµ1 Kwv» (<J:>.E.K. 517/B/1992). 7. Triv un' ap18µ. 14650/t.lOE85/17.3.2004 (<J:>.E.K. 519/B/17.3.2004) Ko1v17An6cpaoriTOu npw8unoupyou KOL Tou Ynoupyou 01Kovoµ(ac; KOL 01Kovoµ1Kwv «Ka8op10µ6c; apµoc510Tl7TWV TWV Ycpunoupywv 01Kovoµ[ac; KOL OLKOVO­ µLKWV». 8. Tic; c5LOT0.S£Lc; TOU 6.p8pou 29 A TOU V. 1558/1985 (<J:>.E.K. 137/A/1985) 6nwc; TO 6.p8po QUTO npoon:8J"]K£ µ£ TO 6.p8po 27TOU V. 2081/1992 (<J:>.E.K. 154/A/1992) KOL OVTL­ KQTQOT0.8J"]K£ an6 TO 6.p8po 1 nap. 2a TOU V. 2469/1997 (38 A) KOL TO yeyov6c; 6n an6 TJ"]V napouoa an6cpaori c5ev npoKaA£LTOL c5an6.vri oe p6.poc; Tou KpanKou npouno>-.oy1 oµou, anocpao[i;ouµe: EyKp(vouµe TJ"]V an6cpaori un' ap18µ. 73/2005 TOu Avw­ TOTOu Xriµ1Kou ruµpou}\.[ou ri ono[a e}\.17cp8J"] Km6. TT'] ouve­ c5p(aori TJ"]c; 24.2.2005 KOL ri ono(a txe1 we; aKoAou8wc;: 1ENIKO XHMEIO TOY KPATOY2 ANOTATO XHMIKO i:YMBOY/\10 EyKp(vouµe TJ"]V Tponono(riori Tou 6:p8pou 36 TOu Kwc51 Ka Tpocp(µwv oe evapµ6v1ori npoc; TJ"]V Oc5riy(a 2003/95/E.K. TJ"]c; En1Tpon17c; (L 283/31.10.2003), y1a TJ"]V Tpononofriori TJ"]c; oc5riyfac; 96/77 /EK nep( Swnfoewc; e1cS1 Kwv KPLTJ"]p(wv Ka8ap6TJ"]TOc; y1a TO np6o8£TO Tpocp(µwv nAJ"]V TWV XPWOTLKWV KOL TWV YAUK□VTLKWV UAWV. To nap6.pTJ"]µa Tou Ap8pou 36 TOu Kwc51Ka Tpocp(µwv TpOnOnOL£LTOL we; £s'7c;: 1. To K£[µevo axsnK6. µe TO v1Tp1K6 6.t..ac; vmp[ou E 251 OVTIK08LOTOTOL we; es11c;: «E 251 NITPIKO NATPIO 1. HEPEO NITPIKO NATPIO i:uvwvuµa Op10µ6c; Xriµ1K17 ovoµao(a ap18. EINECS XJ"]µLK6c; Tunoc; Mop1aK6 p6.poc; LloK1µao(a TauTono(riari A. 0£TLK!::c; c50K1µtc; VITPIKWV IOVTWV KOL vmp(ou B.pH c51aMµmoc; 5% Ka8ap6TJ"]TO Anw>-.e1a Km6. TJ"]V s11pavori N(Tpo TJ"]c; X1Mc; N1TpLK'7 o6c5a N1Tp1K6 v6.Tp10 231-554-3 NaN03 85,00 nepl£KTIKOTJ"]TO TOUAO:XLOTOV 99 % µ£TO. an6 s11pavori /\£UK'7, KpUOTQAAIK'7, £Aacppwc; uypoOKOTIIK'7 OKOVJ"] Tou>--ax10Tov 5,5 KOL ox1 6x1 ul!JriMrnpo an6 8,3 2% KOT' QVWTQTO 6p10 µn6. an6 s11pavori oe 105 ° c en[ 4 wpec; 10702 NtTpWcirJ OAOTO Ap08VLKO M6Au~cioc; Ycip6pyupoc; E 251 NITPIKO NATPIO 2. Y1PO NITPIKO NATPIO Optaµ6c; XriµLKTJ ovoµaa(a Apt8. EINECS XrJ µtK6c; TUnoc; MoptaK6 ~6poc; .6.oKtµaa(a neptypacpf] TauTono(riari A. 08TIK8c; ciOKLµec; YLO TO VLTPLK6 Mac; Km yta TO v6Tpto B.PH Ka8ap6TrJTO EAeu8epo vtTptK6 osu NtTpWcirJ OAOTa Ap08VLKO M6Au~cioc; E<l>HMEPII THI KYBEPNHIEOI (TEYXOI ~EYTEPO) 30 mg/kg KOT' avwTOTO 6p10, eKcppaaµeva ae NaN02 3 mg/kg KOT' avwTOTO 6pto 5 mg/kg KOT' avwTOTO 6pto 1 mg/kg KOT' avwTOTO 6p10 To uyp6 VLTpLK6 v6Tpto dvm TO ucianK6 ci16Auµa v1TptKOU vOTp(ou we; TO 6µeao QTIOT8AWµa TrJc; XflµLKT]c; QVT(cipaaric; µnasU TOU uciposetci(ou TOU VOTp(ou KOL TOU VtTptKOL! o~8oc; CTE ITTOLX8toµeTptK6 noa6, XWp(c; VO 8TI8TQL Kpum6Mwari. Ot TUTIOTIOLrJµ8V8c; µopcpec; nou napaaKeu6i:;oVTm an6 TO uyp6 VLTPLK6 v6Tp1onou QVTQTIOKplV8TQl a' auTec; nc; npocitaypacpec; µnopouv va neptexouv VLTptK6 osu ae nep(aaeta, 80V cirJAWVOVTQl T] 8TILOflµO(VOVTQl aacpwc;. NLTPLKO VOTplO 231-554-3 NaN03 85,00 nepL8KTLKOTrJTO µernsu 33,5%Km40,0 % NaN03 .6.tauyec; axpwµo uyp6 TOUAOXLITTOV 1,5 KOL OXL OVWTOU3,5 0,01 %KOT'avwrnT06pto 10 mg/kg KOT' avwTOTO 6pto eKcppaaµeva ae NaN02 1 mg/kg KOT' avwTOTO 6p10 1 mg/kg KOT' avwTOTO 6pto Ycip6pyupoc; AuTf] ri npocitaypacpf] avacpepnm ae ucianK6 .6.t6Auµa 35 %» 0,3 mg/kg KOT' avwTOTO 6p10 2. Ta Kdµeva oX8TLKO µe TOE 431 OT8QTLK6 TIOAUOsum 8uMvLO (40), E 432 µovOAOUplKT] TIOAUOsu-m8UA8VO-aop­ ~ITOVrJ (poly- sorbate 20), E 433 µov08A0°LKT] TIOAUOsu-m 8UA8VO-aop~LTOVrJ (polysorbate 80), E 434 MovonaAµTLKT] TIOAUOsu-m8UA8VO- aop~lTOVrJ (polysorbate 40), E 435 µovOOT80TlKT] TIOAUOsu-m8UA8VO-aop~LTOVrJ (polysor­ bate 60) KOL E 436 TplOT80TlKT] TIOAUOsU-OL8UA8VO-OOp~l­ TOVrJ (polysorbate 65) aVTLKa8(maVTm we; esfic;: «E 431 HEATIKO nO/\YO=YAl0Y/\ENIO (40) 2uvwvuµa Stearate Polyoxyl (40) 2T80TLK6 TIOAUOSUAIO (40) Optaµ6c; .6.oKtµaa(a TauTono(riari A. .6.tOAUTOTrJTO B. nep1oxfi ariµdou nfisric; 1. Cf>6aµa unepu8pric; anopp6cpriaric; Ka8ap6TrJTO Yypaa(a Ba8µ6c; osUTrJTOc; Ap18µ6c; aanwvono(riaric; MOVOOT80TLKO TIOAUOsU­ OL8UA8VlO (40) 'Eva µe(yµa µovo-Km 51 eurepwv TOU ei5wi5tµou OT80TLKOU osfoc; TOU eµnop(ou µe µdyµa TIOAUOsum8UA8VO­ ciLOAWV (µe µfoo µf]KOc; noAuµepouc; nep(nou 40 µov6ciwv osum8uAev(ou) µal;( µe eAeu8epec; TIOAUQAKOOA8c;. nepteKnK6Trirn TOUA6x1mov 97,5 % en( sripac; oua(ac; Ntcp6ciec; Kpeµ xpwµOToc; ri KrJpwciec; mepe6 moue; 25 °C, µe QTIOTIVLKTIKT] oaµf] 'Evwari citaAUTTJ mo uciwp, TrJV m8av6ArJ, Tfl µe8aVOArJ KOL TOV OsLKO m8uAemepa Acit6AUTrJ OTO OpUKT8AOIO 39 °C-44 °C To xapOKTrJPLITTLKO cp6aµa Tou npo'i6VToc; µep1Kf]c; emepono(riaric; Amapwv osewv µe TIOAUOsum8UALWµ8V8c; TIOAUQAKOOA8c; 3% KOT' QVWTOTO 6p10 (µe8ocioc; Karl Fischer) 1 KOT' avwTOTO 6pto TouMx1mov 25 KOL 6x1 neptaa6Tepo an6 35 E<l>HMEPII THI KYBEPNHIEOI (TEYXOI ~EYTEPO) 10703 Ap18µ6c; u5posuAiwv A1euA.evose1510 TouM.x1arnv 27 KOL 6x1 nep1aa6Tepo on6 40 5 mg/kg KOT' OVWTOTO 6p10 0,2 mg/kg KOT' ovwTOTO 6p10 A18uA.8voyA.uK6A.8c; (µovo-KOL 51-) 0,25 % KOT' ovci:>TOTO Ap08VlKO Y5papyupoc; Ka5µ10 6p10 3 mg/kg KOT' ovWTOTO 6p10 5 mg/kg KOT' ovwTOTO OplO 1 mg/kg KOT' ovwTOTO 6p10 1 mg/kg KOT' ovci:>TOTO 6p10 E 432 MONOMYPIKH nO/\YO::Y-Al0Y/\ENO-IOPBI­ TANH (POLYSORBATE 20) Iuvwvuµo Op10µ6c; .6.0K1µoa(o nep1ypocpr'] TOUTOTIOLl']Ol'] A. .6.I0/1.UTOTl']TO Polysorbate 20 MOVOA.OUplKr'] TIOA.UOsU­ OL8UA.8VO (20) aopl31Tavri Me(yµo TWV npo'i6VTWV µep1Kr']c; wTepono(riaric; aopl31T6Al']c; KOL Twv µovo- KOL 51- ovu5p1T1Kwv nopoywywv µe TO 85W5lµO A.OU plKO OSIJ TOU eµnop(ou KOL UUtJ,1 lUr\.VWtJ,C:vu f,-lC.. nep(nou 20 µ6p10 OL8UA.8VOs815(ou ova µ6p10 aopl3LTOAl']c; KOL ovu5p1Twv Tl']c; nep1eKnK6TrJTO ae osuOL8uMv10 TOUA.ax1mov 70 %, 1a0Mvoµri µe nep18KTL­ KOTrJTO 08 TIOA.UOsU­ OL8UA.8VO (20) µovOAOU­ p1Kr'] aopl31Tavri nep1aa6Tepo on6 97,3 % en( sripac; oua(oc; KiTp1vo ewe; K8xp1µno­ p6xpwµo 8AOLci:>5ec; uyp6 moue; 25 ° C µe xopOKTl']plmlKr'] OTIOTIVIKTIKr'] oaµr'] 'Evwari 510/1.UTr'] mo u5wp, TrJV OL8ov6ArJ, TI'] µe8ov6A!'], TOV os1K6 OL8UA.8mepo KOL TI'] 51osavrJ. A51aA.UTI'] a8 OpUKTeA.OLO KOL TOV TI8Tp8A.0.LKO OL8epo B. <l>aaµo unepu8pric; onopp6cpriaric; Ko8op6T!']TO Yypoa(o Bo8µ6c; osUTl']TOc; Ap18µ6c; aonwvono(riaric; Ap18µ6c; u5posuAiwv To xopoKTrJp1m1K6 cpaaµo TWV npo'i6VTWV µep1Kr']c; emepono(riaric; /1.ITIOpWV osewv µ8 TIOA.U0SUOL8UA.IWµevec; TIOA.UOA.KOOA.8c; 3% KOT' OVWTOTO 6p10 (µe8o5oc; Karl Fischer) 2 KOT' OVWTOTO 6p10 TouA.ax1mov 40 KOL ox1 6.vwTOU 50 TouMx1mov 96 KOL 6x1 aVWTOU 108 5 mg/kg KOT' ovci:>TOTO 6p10 0,2 mg/kg KOT' ovwTOTO 6p10 A18UA.8VOYAUK6A.8c; (µovo-KOL 51-) 0,25 % KOT' ovwTOTO Ap08VIKO Y5papyupoc; K65µ10 6p10 3 mg/kg KOT' ovci:>TOTO 6p10 5 mg/kg KOT' ovci:>TOTO 6p10 1 mg/kg KOT' ovwTOTO 6p10 1 mg/kg KOT' ovwTOTO 6p10 E 433 MONOEM'iKH nO/\YO::Y-Al0Y/\ENO-IOPBITA­ NH (POLYSORBATE 80) Iuvwvuµo Op1aµ6c; .6.0K1µoa(o nep1ypocpr'] Polysorbate 80 MOV08A.0°iKr'] TI0/1.UOSU OL8UA.8VO (20) aopl31Tavri Me(yµo TWV npo'i6VTWV µep1Kr']c; emepono(riaric; aopl31T6Al']c; KOL Twv µovo-KOL 51-ovu5p1Twv Tr]c; µe e5w51µ0 8Aa'iK6 osu TOU eµnop(ou KOL auµnuKvwµevo µe nep(nou 20 µ6p10 OL8UA.8VOs815(ou ova µ6p10 aopl31T6Al']c; KOL TWV ovu5p1Twv Tl']c; nepl8KTIKOTl']TO ae osu­ OL8UA.£VIO TOUA.ax1mov 65 %, nou 1ao5uvoµe( µe n8pl8KTIKOT!']TO ae µOV08A.O.iKr'] TIOA.U0SU­ OL8UA.8VO (20) aopl31Tavri TOUA.ax1mov 96,5 % en( sripac; oua(oc; KiTpLVO ewe; K8Xptµno­ poxpwµo 8AOLci:>5ec; uyp6 moue; 25 ° C µe XOPOKTl']plmlKr'] OTIOTIVIKTLKr'] oaµr'] 10704 E<l>HMEPII THI KYBEPNHIEQI (TEYXOI .6EYTEPO) Tournnofriori A. LiLOAUTOTrJTO B.$6oµounepu8pric; onopp6cprioric; Ko8op6TrJTO Yypoofo Bo8µ6c; OsLJTrJTOc; Apt8µ6c; oonwvonofrioric; Apt8µ6c; uciposuAfwv 1,4-citosavri Ateu}..evosdcito 'Evwori cit0Aun7 mo uciwp, TrJV OL8ov6ArJ, Tfl µe8ov6ArJ, TOV osLKO OL8UA£0T£p0 KOL TO TOAOUOALO. AciLOAUTrJ OTO OpUKT8AOLO KOL TOV TI£Tp£A0°LKO OL8£p0 To xopOKTrJPLOTLKO cp6oµo Twv npo"(6VTwv , , I 1,-.,...11✓-I"'\ r-...-.-rr-. TT l ....... 1--'C,t,JU'\.I I'-, c,v LVt,JV• lVll 1v1 I"> Amopwv ostwv µe TIOAUOSUOL8UALWµ£V£c; TIOAUOAKOOA£c; 3% KOT' ovwTOTO 6pto (µe8ocioc; Karl Fischer) 2 KOT' OVWTQTO 6pl0 TOUAOXLOTOV 45 KOL OXL TI£PLOOOT£PO on6 55 TouMxtmov 65 KOL 6XL neptoo6Tepo on6 80 5 mg/kg KOT' ovwTOTO 6pto 0,2 mg/kg KOT' ovwTOTO 6pto At8uA.£voyAuK6A£c; (µovo-KOL cit-) 0,25 % KOT' ovwTOTO Ap0£VLK6 M6Aul3cioc; Ycip6pyupoc; K6ciµLo 6pto 3 mg/kg KOT' ovwTOTO 6pl0 5 mg/kg KOT' ovwTOTO 6pto 1 mg/kg KOT' OVWTOTO 6pto 1 mg/kg KOT' ovwTOTO 6pto E 434 MONOnA/\MITIKH nO/\YO::Y-Al0Y/\ENO-IOP­ BITANH (POLYSORBATE 40) Iuvwvuµo Optoµ6c; Polysorbate 40 M ovonoAµmKr'] TIOAUOsU- OL8UA£VO (20) oopl3LTOVrJ Mdyµo Twv npo"i6VTwv µeptKr']c; emeponofrioric; TrJc; oopl3LTOArJc; KOL µovo-KOL cit-ovucipmKwv nopoywywv TrJc; µ£ £()(.()C)Lµo noAµLTLKO osu mu eµnop(ou KOL ouµnuKvwµtvo µe nep(nou 20 µ6pto OL8uAevosetcifou ova µ6pto oopl3LTOArJc; KOL ovuciptTwv TrJc; LioKtµoo(o neptypocpr'] Tournnofriori A. LiLOAUTOTrJTO B.$6oµountpu8pric; onopp6cprioric; Ko8op6TrJTO Yypaa(a Bo8µ6c; osUTrJTOc; Apt8µ6c; oonwvonofrioric; Apt8µ6c; uciposuAfwv 1,4-citosavri At8UA£VOS£LC)l0 nepteKnK6TrJTo oe osuOLAUAE:VlO TOUAOXLOTOV 66 %, nou toociuvoµd µe nepL£KTL­ KOTrJTO oe µovonOAµLTLKll noAuosu-OL8UA£V0(20) oopl3tT6vri TOUAOXLOTov 97 % rn( sripac; ouo(oc; K(TplVO npoc; nopTOKO­ Mxpouv £AOLWci£c; uyp6 f] r,~unT7KTc.u~ta moue; 25 ° C µe xopo­ KTrJPLOTLKll OTIOTIVLKTLKl7 00µ17 'Evwori ciLOAUT17 OTO uciwp, TrJV OL8ov6Afl, Tfl µe8ov6ArJ, rnv ostK6 OL8UA£0T£p0 KOL TrJV OK£TOVrJ. AciLOAUTrJ OTO opuKT8AOLO. To xopOKTrJPLOTLKO cp6oµo TWV npo"i6VTWV µeptKr']c; emeponofrioric; Amopwv ostwv µe TIOAUOsuOL8UALWµevec; TIOAUOAKOOA£c; ~OL 1.11'tT' n,11:,TnTn Ap1" (µe8ocioc; Karl Fischer) 2 KOT' ovwTOTO 6pto TOUAOXLOTOV 41 KOL OXL OVWTOU 52 TouMxtmov 90 KOL 6XL OVWTOU 107 5 mg/kg KOT' ovwTOTO OplO 0,2 mg/kg KOT' ovwTOTO 6pto At8uA£voyAuK6Aec; (µovo-KOL cit-) 0,25 % KOT' ovwTOTO Ap0£VLK6 M 6Au l3cioc; Ycip6pyupoc; K6ciµto 6pto 3 mg/kg KOT' ovwTOTO OplO 5 mg/kg KOT' ovwTOTO OplO 1 mg/kg KOT' ovwToTO 6pto 1 mg/kg KOT' ovwTOTO 6pto E 435 MONOHEATIKH no/\YO::Y-Al0Y/\EN0-20PBI­ TANH (POLYSORBATE 60) Iuvwvuµo Polysorbate 60 MovOOT£OTLKl7 TIOAUOsU-OL8UA£VO (20) oopl3LTOVrJ E<l>HMEPII THI KYBEPNHIEnI (TEYXOI .aEYTEPO) 10705 Optoµ6c; LloKtµoo(o neptypocpr'] TouTono(riori A. Ll10AuT6TrJTO B. <1>60µ0 unepu8pric; onopp6cprioric; Ko8op6TrJTO Yypoo(o Bo8µ6c; OSUTT"]Tac; Apt8µ6c; oonwvono(rioric; Apt8µ6c; u5posuMwv 1 ,4-5LOSCIVT"] Me(yµo TWV npo'i6VTWV µeptKr']c; wTepono(rioric; oopl3LTOAT"]c; KOL TWV µ6vo KOL ciL- ovucipmKwv nopoywywv Tr]c; µe e5w5tµo mrnnK6 osu Tou eµnop(ou KOL ouµnuKvwµevo µe nep(nou 20 µ6pto OL8U/\8VOS8Lci(ou ova µ6pto oopl3LTOAT"]c; KOL ovu5ptTwv TT"]c; nepteKTLKOTrJTO oe osu­ OL8uMvto TOUAOXLOTov 65 %, nou too5uvoµe( µe TI8pl8KTLKOTT"]TO 08 µOVOOT80TLKr'] TIO/\UOSU­ OL8U/\8VO (20) oopl3LTCIVT"] TOUAClXLOTOV 97 % en( sripac; ouo(oc;. KiTpLVO npoc; nopTOKO uyp6 r'] riµmr']KTwµo moue; 25 ° C µe XOPOKTT'JplOTLKr'] OTIOTIVLKTLKr'] ooµr'] 'Evwori C)LO/\UTr'] OTO UciWp, TOV OSIKO OL8U/\8 0T8p0 KOL TO TO/\OUO/\LO. 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'Evwori ciLO/\UTr'] OTO opuKTeAmo, TO cpunKa 8/\0LO, TOV TI8Tp8AO.iK6 m8epo, TT"]V OK8TOVT"], TOV OL8epo, TT"] C)LOSCIVT"], Tr]V OL8ov6Ar] KOL TT"] µe8ov6Ar] 29-33 °C To xopoKTrJPLOTLK6 cpaoµo TWV npo'(OVTWV Tr]c; µepLKr']c; 80T8p0 TIOLT"]OT"]c; Amopwv osewv µe TIO/\UOSUOL8U/\LWµE­ V8C: TIO/\UO/\KOOA8c; 3% KOT' OVWTOTO 6pLO (µe8o5oc; Karl Fischer) 2 KOT' ovwTOTO 6pto TOU/\OXLOTOV 88 KOL OXL CIVWTOU 98 10706 E<bHMEPII THI KYBEPNHIEnI (TEYXOI aEYTEPO) Apt8µ6c; uciposuAfwv 1 ,4-citosavri Ateul\evosdcito TOUAOXLOTOV 40 KOL OXL Cl.VWTOU 60 5 mg/kg KOT' OVWTOTO 6pto 0,2 mg/kg KOT' avwTOTO 6pto A18u1'£voyAuK6Aec; (µovo-KOL 51-) 0,25 % KOT' avwTOTO Ap0£VIKO M 6Au f3cioc; Ycip6.pyupoc; K6.ciµto 6pto 3 mg/kg KOT' avwTOTO 6pto 5 mg/kg KOT' avwTmo 6pl0 1 mg/kg KOT' avwTmo 6pto 1 mg/kg KOT' avwrnTO 6pto» 3. To Kdµevo oX£TLKCI µ£ Tl']V E 459 f3r']TO-KUKAOci£sTPLVI'] OVTIK08(0TOTOL we; £sr']c;: «E 459 BHTA-KYK/\0.LlE::TPINH Op10µ6c; Xl']µLKrJ ovoµao(a Apt8. 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To Kdµevo oxenK6. µe TrJV no1'uOLl\ul\evoy1'uK6ArJ 6000 OVTLK08LOTOTOL we; £sr'Jc;: «nO/\YAl0Y/\EN01/\YKO/\H 6000 fovwvuµa Optoµ6c; Xl']µLK6c; Tunoc; MopLOKO [36.poc; LloKtµao(a neptypacpr'] TauTOno(riori A. ilLOAUTOTl']TO B. neptoxr'J oriµdou TrJsl'lC: Ka8ap6T!']TO lswciec; Apt8µ6c; uciposuAfwv PEG 6000 Macrogol 6000 H TIOAUOL8UA£VOVAUKOAI'] 6000 dvOL µdyµa nol\uµepwv µeTOyevtK6 Tuno H - (OCH2 -CH) -OH nou OVTIOTOLXf:l 0£ µta µ80!'] oX£TLKrJ µopLOKrJ µ61:;a nep(nou 6000 (C2H40)n H2o (n = apt8µ6c; µovaciwv OL8UA£VOS£Lci(ou TIOU OVTLOTOLXOUV oe µop1aK6 [36.poc; 6000, nep(nou 140) 5 600 - 7 000 TOUAOXLOTOV 90,0 % KOL OXL nep1006rnpo an6 110,0 % /\wK6 r'] axeMv 1'£uK6 OT£p£6 µ£ Kl']pWci!'] r'] napacp1vwciri µopcpr'] 'Evwari £UKOAO ciLOAUTrJ OTO uciwp KOL OTO µ£8UA£VOXAWptciLO. 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A8f]va, 16 Ma:fou 2005 0 YnOYP,m: 0 Yct>YnOYP,m: OIKONOMIAL KAI OIKONOMIKON OIKONOMIAL KAI OIKONOMIKON nnPrOI AJ\OrOIKOY<l>HI MAM PErKOYZAI 10707